HUBUNGAN CD4 BASELINE, STATUS KLINIS DAN VIRAL LOAD PADA PASIEN HIV/AIDS DI RSUD dr. RUBINI KABUPATEN MEMPAWAH

Human Immunodeficiency Virus (HIV) and Acquired Immunodeficiency Syndrome (AIDS) attack the immune system, involving three main parameters: CD4 count as an immunological indicator, viral load as a virological indicator, and clinical status as a reflection of patient condition. In patients on ARV therapy, differences in relationship patterns among these parameters often emerge. This study aims to analyze the relationship between baseline CD4, clinical status, and viral load, and to observe the role of clinical status as an intervening variable. An analytical observational design with a cross-sectional approach was used. The sample comprised secondary data from HIV/AIDS patients at Dr. Rubini Regional General Hospital in Mempawah Regency from 2023 to 2025, totaling 41 data points obtained via purposive sampling, with the criterion that patients were adherent to ARV consumption for at least 6 months. Spearman's rank correlation analysis showed a moderately strong and significant negative correlation between baseline CD4 levels and clinical status (r = -0.568), (p = 0.000), leading to the acceptance of the alternative hypothesis (Ha). However, no significant correlation was found between clinical status and viral load (p = 0.241) or between baseline CD4 and viral load (p = 0.515). This indicates a clinical-virological dissociation, where viral suppression after six months of therapy is more dominantly influenced by ARV efficacy than by initial clinical manifestations.